Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues

[Image: see text] Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The iso-MGS biosynthetic machinery f...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Seo, Jeong-Woo, Ma, Ming, Kwong, Thomas, Ju, Jianhua, Lim, Si-Kyu, Jiang, Hui, Lohman, Jeremy R., Yang, Chunying, Cleveland, John, Zazopoulos, Emmanuel, Farnet, Chris M., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270375/
https://ncbi.nlm.nih.gov/pubmed/25405956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501396v
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