iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Genome scanning of Streptomyces platensis NRRL 18993 unveiled two candidate gene clu...

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Bibliografische gegevens
Hoofdauteurs: Lim, Si-Kyu, Ju, Jianhua, Zazopoulos, Emmanuel, Jiang, Hui, Seo, Jeong-Woo, Chen, Yihua, Feng, Zhiyang, Rajski, Scott R., Farnet, Chris M., Shen, Ben
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
Onderwerpen:
Metabolism and Bioenergetics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785606/
https://ncbi.nlm.nih.gov/pubmed/19726666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046805
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