iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Genome scanning of Streptomyces platensis NRRL 18993 unveiled two candidate gene clu...

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Detalhes bibliográficos
Main Authors: Lim, Si-Kyu, Ju, Jianhua, Zazopoulos, Emmanuel, Jiang, Hui, Seo, Jeong-Woo, Chen, Yihua, Feng, Zhiyang, Rajski, Scott R., Farnet, Chris M., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785606/
https://ncbi.nlm.nih.gov/pubmed/19726666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046805
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