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The Post-polyketide Synthase Steps in iso-Migrastatin Biosynthesis Featuring Tailoring Enzymes with Broad Substrate Specificity

The iso-migrastatin (iso-MGS) biosynthetic gene cluster from Streptomyces platensis NRRL 18993 consists of 11 genes, featuring an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes MgsIJK. Systematic inactivation of mgsIJK in S. platensis enabled us to (i) identif...

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Detalhes bibliográficos
Main Authors: Ma, Ming, Kwong, Thomas, Lim, Si-Kyu, Ju, Jianhua, Lohman, Jeremy R., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582021/
https://ncbi.nlm.nih.gov/pubmed/23394593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4002635
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