P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140. Both in vivo and in vitro characterization of the LNM biosynthetic machinery have established the formation of the 18-membered macrolactam backbone and the C-3 alkyl branch; the nascent product, LNM E1, o...

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Pubblicato in:Biochemistry
Autori principali: Kwong, Thomas, Ma, Ming, Pan, Guohui, Hindra, Yang, Dong, Yang, Chunying, Lohman, Jeremy R., Rudolf, Jeffrey D., Cleveland, John L., Shen, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211295/
https://ncbi.nlm.nih.gov/pubmed/30070831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00623
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