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Engineered Production of iso-Migrastatin in Heterologous Streptomyces Hosts
Glutarimide-containing polyketides such as migrastatin (MGS) are well known for their ability to inhibit tumor cell migration. We have previously shown that MGS is derived from iso-migrastatin (iso-MGS) via a H(2)O-mediated ring-expansion rearrangement. A bacterial artificial chromosome (BAC) librar...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075207/ https://ncbi.nlm.nih.gov/pubmed/19010685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.074 |
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