Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

[Image: see text] C-1027 is a chromoprotein enediyne antitumor antibiotic produced by Streptomyces globisporus. In the last step of biosynthesis of the (S)-3-chloro-5-hydroxy-β-tyrosine moiety of the C-1027 enediyne chromophore, SgcE6 and SgcC compose a two-component monooxygenase that hydroxylates...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Chang, Chin-Yuan, Lohman, Jeremy R., Cao, Hongnan, Tan, Kemin, Rudolf, Jeffrey D., Ma, Ming, Xu, Weijun, Bingman, Craig A., Yennamalli, Ragothaman M., Bigelow, Lance, Babnigg, Gyorgy, Yan, Xiaohui, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024704/
https://ncbi.nlm.nih.gov/pubmed/27560143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00713
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items