Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027

BACKGROUND: C-1027, produced by Streptomyces globisporus C-1027, is one of the most potent antitumoral agents. The biosynthetic gene cluster of C-1027, previously cloned and sequenced, contains at least three putative regulatory genes, i.e. sgcR1, sgcR2 and sgcR3. The predicted gene products of thes...

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Detalhes bibliográficos
Main Authors: Wang, Lifei, Hu, Yunfeng, Zhang, Yanjuan, Wang, Songmei, Cui, Zhihui, Bao, Yi, Jiang, Wei, Hong, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657911/
https://ncbi.nlm.nih.gov/pubmed/19159491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-14
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