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Improvement of the Enediyne Antitumor antibiotic C-1027 Production by Manipulating its Biosynthetic Pathway Regulation in Streptomyces globisporus

The production of C-1027 in Streptomyces globisporus was previously increased two- to three-fold by manipulating three pathway specific activators, SgcR1, SgcR2, and SgcR3. In this study, we have further characterized two putative C-1027 regulatory genes, sgcE1 and sgcR, by in vivo inactivation. The...

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Hlavní autoři: Chen, Yihua, Yin, Min, Horsman, Geoff P, Shen, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064734/
https://ncbi.nlm.nih.gov/pubmed/21250756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100825y
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