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Improvement of the Enediyne Antitumor antibiotic C-1027 Production by Manipulating its Biosynthetic Pathway Regulation in Streptomyces globisporus
The production of C-1027 in Streptomyces globisporus was previously increased two- to three-fold by manipulating three pathway specific activators, SgcR1, SgcR2, and SgcR3. In this study, we have further characterized two putative C-1027 regulatory genes, sgcE1 and sgcR, by in vivo inactivation. The...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064734/ https://ncbi.nlm.nih.gov/pubmed/21250756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100825y |
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