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Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

Manipulation of pathway regulation is an efficient strategy to increase specific secondary metabolite production. Here we successfully improved production of both the enediyne antitumor antibiotic C-1027 and a heptaebe, an early metabolite of the C-1027 pathway, by manipulating the three regulatory...

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Detalles Bibliográficos
Main Authors: Chen, Yihua, Yin, Min, Horsman, Geoff P., Huang, Shengxiong, Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929275/
https://ncbi.nlm.nih.gov/pubmed/20551990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2010.55
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