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Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC That Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
C-1027 is a potent antitumor antibiotic composed of an apoprotein (CagA) and a reactive enediyne chromophore. The chromophore has four distinct chemical moieties, including an (S)-3-chloro-5-hydroxy- β-tyrosine moiety, the biosynthesis of which from L-α-tyrosine requires five proteins: SgcC, SgcC1,...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312381/ https://ncbi.nlm.nih.gov/pubmed/18426211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710601d |
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