Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

C-1027 is a chromoprotein enediyne antitumor antibiotic, consisting of the CagA apo-protein and the C-1027 chromophore. The C-1027 chromophore features a nine-membered enediyne core appended with three peripheral moieties, including an (S)-3-chloro-5-hydroxy-β-tyrosine. In a convergent biosynthesis...

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Publié dans:Biochemistry
Auteurs principaux: Chang, Chin-Yuan, Lohman, Jeremy R., Huang, Tingting, Michalska, Karolina, Bigelow, Lance, Rudolf, Jeffrey D., Jedrzejczak, Robert, Yan, Xiaohui, Ma, Ming, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips,, George N., Shen, Ben
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219380/
https://ncbi.nlm.nih.gov/pubmed/29533601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00174
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