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Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradigm. They lack the integrated AT domains within their modules and instead use a discrete AT that acts in trans, whereas a type I PKS module minimally contains AT, acyl carrier protein (ACP), and ketosynthase (KS)...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Lohman, Jeremy R., Ma, Ming, Osipiuk, Jerzy, Nocek, Boguslaw, Kim, Youngchang, Chang, Changsoo, Cuff, Marianne, Mack, Jamey, Bigelow, Lance, Li, Hui, Endres, Michael, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611616/
https://ncbi.nlm.nih.gov/pubmed/26420866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515460112
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