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Utilizing the GAAA tetraloop/receptor to facilitate crystal packing and structure determination of a CUG RNA helix
Myotonic dystrophy type 1 (DM1) is a microsatellite expansion disorder caused by the aberrant expansion of CTG repeats in the 3’ untranslated region of the DMPK gene. When transcribed, the toxic RNA CUG repeats sequester RNA binding proteins, which leads to disease symptoms. The expanded CUG repeats...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3515634/ https://ncbi.nlm.nih.gov/pubmed/23025897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300829w |
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