Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models

Myotonic Dystrophy type 1 (DM1) is an inherited disease characterized by the inability to relax contracted muscles. Affected individuals carry large CTG expansions that are toxic when transcribed. One possible treatment approach is to reduce or eliminate transcription of CTG repeats. Actinomycin D (...

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Publicado no:Cell Rep
Main Authors: Siboni, Ruth B., Nakamori, Masayuki, Wagner, Stacey D., Struck, Adam J., Coonrod, Leslie A., Harriott, Shanee A., Cass, Daniel M., Tanner, Matthew K., Berglund, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691565/
https://ncbi.nlm.nih.gov/pubmed/26686629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.028
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