Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models

Myotonic Dystrophy type 1 (DM1) is an inherited disease characterized by the inability to relax contracted muscles. Affected individuals carry large CTG expansions that are toxic when transcribed. One possible treatment approach is to reduce or eliminate transcription of CTG repeats. Actinomycin D (...

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Udgivet i:Cell Rep
Main Authors: Siboni, Ruth B., Nakamori, Masayuki, Wagner, Stacey D., Struck, Adam J., Coonrod, Leslie A., Harriott, Shanee A., Cass, Daniel M., Tanner, Matthew K., Berglund, J. Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691565/
https://ncbi.nlm.nih.gov/pubmed/26686629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.028
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