Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

[Image: see text] Enediynes are potent natural product anticancer antibiotics, and are classified as 9- or 10-membered according to the size of their enediyne core carbon skeleton. Both 9- and 10-membered enediyne cores are biosynthesized by the enediyne polyketide synthase (PKSE), thioesterase (TE)...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Annaval, Thibault, Rudolf, Jeffrey D., Chang, Chin-Yuan, Lohman, Jeremy R., Kim, Youngchang, Bigelow, Lance, Jedrzejczak, Robert, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579567/
https://ncbi.nlm.nih.gov/pubmed/28884166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00933
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