Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges

Por Lehmann-Horn, Klaus, Kronsbein, Helena C., Weber, Martin S.
Publicado em 2013

Update on the autoimmune pathology of multiple sclerosis: B cells as disease-drivers and therapeutic targets

Por von Büdingen, H.-Christian, Palanichamy, Arumugam, Lehmann-Horn, Klaus, Michel, Brady A., Zamvil, Scott S.
Publicado no Eur Neurol (2015)

B‐cell very late antigen‐4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

Por Lehmann‐Horn, Klaus, Sagan, Sharon A., Bernard, Claude C.A., Sobel, Raymond A., Zamvil, Scott S.
Publicado no Ann Neurol (2015)

B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue

Por Lehmann-Horn, Klaus, Wang, Sheng-zhi, Sagan, Sharon A., Zamvil, Scott S., von Büdingen, H.-Christian
Publicado no JCI Insight (2016)

Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate

Por Spencer, Collin M., Crabtree-Hartman, Elizabeth C., Lehmann-Horn, Klaus, Cree, Bruce A.C., Zamvil, Scott S.
Publicado no Neurol Neuroimmunol Neuroinflamm (2015)

CNS accumulation of regulatory B cells is VLA-4-dependent

Por Lehmann-Horn, Klaus, Sagan, Sharon A., Winger, Ryan C., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Zamvil, Scott S.
Publicado no Neurol Neuroimmunol Neuroinflamm (2016)

Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders

Por Lehmann-Horn, Klaus, Schleich, Eva, Hertzenberg, Deetje, Hapfelmeier, Alexander, Kümpfel, Tania, von Bubnoff, Nikolas, Hohlfeld, Reinhard, Berthele, Achim, Hemmer, Bernhard, Weber, Martin S
Publicado em 2011

Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity

Por Lehmann-Horn, Klaus, Kinzel, Silke, Feldmann, Linda, Radelfahr, Florentine, Hemmer, Bernhard, Traffehn, Sarah, Bernard, Claude C A, Stadelmann, Christine, Brück, Wolfgang, Weber, Martin S
Publicado em 2014

Repetitive Pertussis Toxin Promotes Development of Regulatory T Cells and Prevents Central Nervous System Autoimmune Disease

Por Weber, Martin S., Benkhoucha, Mahdia, Lehmann-Horn, Klaus, Hertzenberg, Deetje, Sellner, Johann, Santiago-Raber, Marie-Laure, Chofflon, Michel, Hemmer, Bernhard, Zamvil, Scott S., Lalive, Patrice H.
Publicado em 2010

HLA-DRB1(∗)0401 and HLA-DRB1(∗)0408 Are Strongly Associated with the Development of Antibodies against Interferon-β Therapy in Multiple Sclerosis

Por Hoffmann, Steve, Cepok, Sabine, Grummel, Verena, Lehmann-Horn, Klaus, Hackermueller, Jörg, Stadler, Peter F., Hartung, Hans-Peter, Berthele, Achim, Deisenhammer, Florian, Wasmuth, Ralf, Hemmer, Bernhard
Publicado em 2008

HLA-DRB1(∗)0401 and HLA-DRB1(∗)0408 Are Strongly Associated with the Development of Antibodies against Interferon-β Therapy in Multiple Sclerosis

Por Hoffmann, Steve, Cepok, Sabine, Grummel, Verena, Lehmann-Horn, Klaus, Hackermüller, Jörg, Stadler, Peter F., Hartung, Hans-Peter, Berthele, Achim, Deisenhammer, Florian, Wassmuth, Ralf, Hemmer, Bernhard
Publicado em 2008

Developmental maturation of innate immune cell function correlates with age-associated susceptibility to central nervous system autoimmunity

Por Hertzenberg, Deetje, Lehmann-Horn, Klaus, Kinzel, Silke, Husterer, Veronika, Cravens, Petra D., Kieseier, Bernd C., Hemmer, Bernhard, Brück, Wolfgang, Zamvil, Scott S., Stüve, Olaf, Weber, Martin S.
Publicado em 2013

Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen

Por Kinzel, Silke, Lehmann-Horn, Klaus, Torke, Sebastian, Häusler, Darius, Winkler, Anne, Stadelmann, Christine, Payne, Natalie, Feldmann, Linda, Saiz, Albert, Reindl, Markus, Lalive, Patrice H., Bernard, Claude C., Brück, Wolfgang, Weber, Martin S.
Publicado no Acta Neuropathol (2016)

B cell activation influences T cell polarization and outcome of anti-CD20 B cell depletion in CNS autoimmunity

Por Weber, Martin S., Prod’homme, Thomas, Patarroyo, Juan C., Molnarfi, Nicolas, Karnezis, Tara, Lehmann-Horn, Klaus, Danilenko, Dimitry M., Eastham-Anderson, Jeffrey, Slavin, Anthony J., Linington, Christopher, Bernard, Claude C.A., Martin, Flavius, Zamvil, Scott S.
Publicado em 2010

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Por Mei, Feng, Lehmann-Horn, Klaus, Shen, Yun-An A, Rankin, Kelsey A, Stebbins, Karin J, Lorrain, Daniel S, Pekarek, Kara, A Sagan, Sharon, Xiao, Lan, Teuscher, Cory, von Büdingen, H-Christian, Wess, Jürgen, Lawrence, J Josh, Green, Ari J, Fancy, Stephen PJ, Zamvil, Scott S, Chan, Jonah R
Publicado no eLife (2016)