B cell activation influences T cell polarization and outcome of anti-CD20 B cell depletion in CNS autoimmunity

OBJECTIVE: Clinical studies indicate that anti-CD20 B cell depletion may be an effective multiple sclerosis therapy. We investigated mechanisms of its immune modulation using two paradigms of experimental autoimmune encephalomyelitis (EAE). METHODS: Murine EAE was induced by either recombinant myeli...

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Detalhes bibliográficos
Main Authors: Weber, Martin S., Prod’homme, Thomas, Patarroyo, Juan C., Molnarfi, Nicolas, Karnezis, Tara, Lehmann-Horn, Klaus, Danilenko, Dimitry M., Eastham-Anderson, Jeffrey, Slavin, Anthony J., Linington, Christopher, Bernard, Claude C.A., Martin, Flavius, Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375897/
https://ncbi.nlm.nih.gov/pubmed/20641064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22081
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