CNS accumulation of regulatory B cells is VLA-4-dependent

OBJECTIVE: To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced in mice selectively deficient for VLA-4 on B cells (CD19cre/α4(f/f)) by immunization with myelin oligodendroc...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Lehmann-Horn, Klaus, Sagan, Sharon A., Winger, Ryan C., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794810/
https://ncbi.nlm.nih.gov/pubmed/27027096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000212
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