Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Treatment with ex vivo–generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases. However, the dynamics and function of T-reg in autoimmunity are not well understood. Thus, we developed Foxp3gfp knock-in (Foxp3gfp.KI) mice and mye...

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Hauptverfasser: Korn, Thomas, Reddy, Jayagopala, Gao, Wenda, Bettelli, Estelle, Awasthi, Amit, Petersen, Troels R, Bäckström, B Thomas, Sobel, Raymond A, Wucherpfennig, Kai W, Strom, Terry B, Oukka, Mohamed, Kuchroo, Vijay K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427780/
https://ncbi.nlm.nih.gov/pubmed/17384649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1564
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