Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by significant neuronal loss in the experimental autoim...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mei, Feng, Lehmann-Horn, Klaus, Shen, Yun-An A, Rankin, Kelsey A, Stebbins, Karin J, Lorrain, Daniel S, Pekarek, Kara, A Sagan, Sharon, Xiao, Lan, Teuscher, Cory, von Büdingen, H-Christian, Wess, Jürgen, Lawrence, J Josh, Green, Ari J, Fancy, Stephen PJ, Zamvil, Scott S, Chan, Jonah R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039026/
https://ncbi.nlm.nih.gov/pubmed/27671734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18246
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