HLA-DRB1(∗)0401 and HLA-DRB1(∗)0408 Are Strongly Associated with the Development of Antibodies against Interferon-β Therapy in Multiple Sclerosis

The formation of antibodies to interferon-beta (IFN-β), a protein-based disease-modifying agent for multiple sclerosis (MS), is a problem in clinical practice. These antibodies may neutralize the biological effects of the protein drug, potentially decreasing its therapeutic effects. By high-resoluti...

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Autori principali: Hoffmann, Steve, Cepok, Sabine, Grummel, Verena, Lehmann-Horn, Klaus, Hackermueller, Jörg, Stadler, Peter F., Hartung, Hans-Peter, Berthele, Achim, Deisenhammer, Florian, Wasmuth, Ralf, Hemmer, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495071/
https://ncbi.nlm.nih.gov/pubmed/18656179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.07.006
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