Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

Por Hüttel, Wolfgang, Spencer, Jonathan B, Leadlay, Peter F
Publicado em 2014

An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics

Por Hong, Hui, Samborskyy, Markiyan, Lindner, Frederick, Leadlay, Peter F.
Publicado no Angew Chem Int Ed Engl (2015)

Phosphorylation of the Periplasmic Binding Protein in Two Transport Systems for Arginine Incorporation in Escherichia coli K-12 Is Unrelated to the Function of the Transport System

Por Celis, Roberto T. F., Leadlay, Peter F., Roy, Ipsita, Hansen, Anne
Publicado em 1998

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Por Hong, Hui, Stinear, Tim, Porter, Jessica, Demangel, Caroline, Leadlay, Peter F
Publicado em 2007

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Por Hong, Hui, Demangel, Caroline, Pidot, Sacha J., Leadlay, Peter F., Stinear, Tim
Publicado em 2008

Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted in rapL, Encoding a Putative Lysine Cyclodeaminase

Por Khaw, Lake Ee, Böhm, Günter A., Metcalfe, Su, Staunton, James, Leadlay, Peter F.
Publicado em 1998

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

Por Hong, Hui, Coutanceau, Emmanuelle, Leclerc, Marion, Caleechurn, Laxmee, Leadlay, Peter F., Demangel, Caroline
Publicado em 2008

Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

Por Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Publicado no Angew Chem Int Ed Engl (2015)

Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

Por Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Publicado no Angew Chem Weinheim Bergstr Ger (2015)

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase

Por Hong, Hui, Sun, Yuhui, Zhou, Yongjun, Stephens, Emily, Samborskyy, Markiyan, Leadlay, Peter F
Publicado no Beilstein J Org Chem (2016)

Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

Por Luhavaya, Hanna, Williams, Simon R, Hong, Hui, Gonzaga de Oliveira, Luciana, Leadlay, Peter F
Publicado no Chembiochem (2014)

In vitro reconstruction of tetronate RK-682 biosynthesis

Por Sun, Yuhui, Hahn, Frank, Demydchuk, Yuliya, Chettle, James, Tosin, Manuela, Osada, Hiroyuki, Leadlay, Peter F.
Publicado em 2009

Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

Por Zhou, Yongjun, Murphy, Annabel C., Samborskyy, Markiyan, Prediger, Patricia, Dias, Luiz Carlos, Leadlay, Peter F.
Publicado no Chem Biol (2015)

Chemical Probes for the Functionalization of Polyketide Intermediates**

Por Riva, Elena, Wilkening, Ina, Gazzola, Silvia, Li, W M Ariel, Smith, Luke, Leadlay, Peter F, Tosin, Manuela
Publicado no Angew Chem Int Ed Engl (2014)

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis

Por Luhavaya, Hanna, Dias, Marcio V B, Williams, Simon R, Hong, Hui, de Oliveira, Luciana G, Leadlay, Peter F
Publicado no Angew Chem Int Ed Engl (2015)

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis

Por Luhavaya, Hanna, Dias, Marcio V. B., Williams, Simon R., Hong, Hui, de Oliveira, Luciana G., Leadlay, Peter F.
Publicado no Angew Chem Weinheim Bergstr Ger (2015)

Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans

Por Stinear, Timothy P., Hong, Hui, Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Garnier, Thierry, Leadlay, Peter F., Cole, Stewart T.
Publicado em 2005

Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII

Por Moncrieffe, Martin C., Fernandez, Maria-Jose, Spiteller, Dieter, Matsumura, Hiroyoshi, Gay, Nicholas J., Luisi, Ben F., Leadlay, Peter F.
Publicado em 2012

Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

Por Guo, Junhong, Huang, Fanglu, Huang, Chuan, Duan, Xiaobo, Jian, Xinyun, Leeper, Finian, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Publicado em 2014

Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

Por Huang, Chuan, Huang, Fanglu, Moison, Eileen, Guo, Junhong, Jian, Xinyun, Duan, Xiaobo, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Publicado no Chem Biol (2015)