Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans

The 174-kb virulence plasmid pMUM001 in Mycobacterium ulcerans epidemic strain Agy99 harbors three very large and homologous genes that encode giant polyketide synthases (PKS) responsible for the synthesis of the lipid toxin mycolactone. Deeper investigation of M. ulcerans Agy99 resulted in identifi...

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Main Authors: Stinear, Timothy P., Hong, Hui, Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Garnier, Thierry, Leadlay, Peter F., Cole, Stewart T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Bacteriophages, Transposons, and Plasmids
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064021/
https://ncbi.nlm.nih.gov/pubmed/15716437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.5.1668-1676.2005
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