Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

Mycobacterium ulcerans (MU), an emerging human pathogen harbored by aquatic insects, is the causative agent of Buruli ulcer, a devastating skin disease rife throughout Central and West Africa. Mycolactone, an unusual macrolide with cytotoxic and immunosuppressive properties, is responsible for the m...

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Detalhes bibliográficos
Main Authors: Stinear, Timothy P., Mve-Obiang, Armand, Small, Pamela L. C., Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Jenkin, Grant A., Johnson, Paul D. R., Davies, John K., Lee, Richard E., Adusumilli, Sarojini, Garnier, Thierry, Haydock, Stephen F., Leadlay, Peter F., Cole, Stewart T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC337055/
https://ncbi.nlm.nih.gov/pubmed/14736915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305877101
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