Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

Mycobacterium ulcerans (MU), an emerging human pathogen harbored by aquatic insects, is the causative agent of Buruli ulcer, a devastating skin disease rife throughout Central and West Africa. Mycolactone, an unusual macrolide with cytotoxic and immunosuppressive properties, is responsible for the m...

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Dades bibliogràfiques
Autors principals: Stinear, Timothy P., Mve-Obiang, Armand, Small, Pamela L. C., Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Jenkin, Grant A., Johnson, Paul D. R., Davies, John K., Lee, Richard E., Adusumilli, Sarojini, Garnier, Thierry, Haydock, Stephen F., Leadlay, Peter F., Cole, Stewart T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC337055/
https://ncbi.nlm.nih.gov/pubmed/14736915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305877101
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