Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice

There is no effective vaccine against Buruli ulcer. In experimental footpad infection of C57BL/6 mice with M. ulcerans, a prime-boost vaccination protocol using plasmid DNA encoding mycolyltransferase Ag85A of M. ulcerans and a homologous protein boost has shown significant, albeit transient protect...

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Detalhes bibliográficos
Main Authors: Roupie, Virginie, Pidot, Sacha J., Einarsdottir, Tobba, Van Den Poel, Christophe, Jurion, Fabienne, Stinear, Timothy P., Huygen, Kris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879250/
https://ncbi.nlm.nih.gov/pubmed/24392169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002604
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