The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

Mycolactones are polyketide-derived lipid virulence factors made by the slow-growing human pathogen, Mycobacterium ulcerans. Three unusually large and homologous plasmid-borne genes (mlsA1: 51 kb, mlsB: 42 kb and mlsA2: 7 kb) encode the mycolactone type I polyketide synthases (PKS). The extreme size...

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Hauptverfasser: Porter, Jessica L., Tobias, Nicholas J., Pidot, Sacha J., Falgner, Steffen, Tuck, Kellie L., Vettiger, Andrea, Hong, Hui, Leadlay, Peter F., Stinear, Timothy P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720922/
https://ncbi.nlm.nih.gov/pubmed/23894666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070520
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