IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection

BACKGROUND: Buruli ulcer is a disease of the skin and soft tissues caused by infection with a slow growing pathogen, Mycobacterium ulcerans. A vaccine for this disease is not available but M. ulcerans possesses a giant plasmid pMUM001 that harbours the polyketide synthase (PKS) genes encoding a mult...

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Veröffentlicht in:PeerJ
Hauptverfasser: Loglo, Aloysius D., Frimpong, Michael, Sarpong Duah, Mabel, Sarfo, Fred, Sarpong, Francisca N., Agbavor, Bernadette, Boakye-Appiah, Justice K., Abass, Kabiru M., Dongyele, Mathias, Frempong, Margaret, Pidot, Sacha, Wansbrough-Jones, Mark, Stinear, Timothy P., Roupie, Virginie, Huygen, Kris, Phillips, Richard O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: PeerJ Inc. 2018
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078848/
https://ncbi.nlm.nih.gov/pubmed/30090691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.5294
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