Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

Mycobacterium ulcerans (MU), an emerging human pathogen harbored by aquatic insects, is the causative agent of Buruli ulcer, a devastating skin disease rife throughout Central and West Africa. Mycolactone, an unusual macrolide with cytotoxic and immunosuppressive properties, is responsible for the m...

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Bibliografiset tiedot
Päätekijät: Stinear, Timothy P., Mve-Obiang, Armand, Small, Pamela L. C., Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Jenkin, Grant A., Johnson, Paul D. R., Davies, John K., Lee, Richard E., Adusumilli, Sarojini, Garnier, Thierry, Haydock, Stephen F., Leadlay, Peter F., Cole, Stewart T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC337055/
https://ncbi.nlm.nih.gov/pubmed/14736915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305877101
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