Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

Mycobacterium ulcerans (MU), an emerging human pathogen harbored by aquatic insects, is the causative agent of Buruli ulcer, a devastating skin disease rife throughout Central and West Africa. Mycolactone, an unusual macrolide with cytotoxic and immunosuppressive properties, is responsible for the m...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Stinear, Timothy P., Mve-Obiang, Armand, Small, Pamela L. C., Frigui, Wafa, Pryor, Melinda J., Brosch, Roland, Jenkin, Grant A., Johnson, Paul D. R., Davies, John K., Lee, Richard E., Adusumilli, Sarojini, Garnier, Thierry, Haydock, Stephen F., Leadlay, Peter F., Cole, Stewart T.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC337055/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14736915/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305877101
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