Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

The complex bis-spiroacetal polyether ionophore salinomycin has been identified as a uniquely selective agent against cancer stem cells and is also strikingly effective in an animal model of latent tuberculosis. The basis for these important activities is unknown. We show here that deletion of the s...

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Detaylı Bibliyografya
Yayımlandı:Chembiochem
Asıl Yazarlar: Luhavaya, Hanna, Williams, Simon R, Hong, Hui, Gonzaga de Oliveira, Luciana, Leadlay, Peter F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: WILEY-VCH Verlag 2014
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515104/
https://ncbi.nlm.nih.gov/pubmed/25155178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402300
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