Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

The complex bis-spiroacetal polyether ionophore salinomycin has been identified as a uniquely selective agent against cancer stem cells and is also strikingly effective in an animal model of latent tuberculosis. The basis for these important activities is unknown. We show here that deletion of the s...

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Bibliografski detalji
Izdano u:Chembiochem
Glavni autori: Luhavaya, Hanna, Williams, Simon R, Hong, Hui, Gonzaga de Oliveira, Luciana, Leadlay, Peter F
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2014
Teme:
Communications
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515104/
https://ncbi.nlm.nih.gov/pubmed/25155178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402300
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