C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease

Por Kleinknecht, Alexandra, Popova, Blagovesta, Lázaro, Diana F., Pinho, Raquel, Valerius, Oliver, Outeiro, Tiago F., Braus, Gerhard H.
Publicado no PLoS Genet (2016)

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

Por Lázaro, Diana F., Dias, Mariana Castro, Carija, Anita, Navarro, Susanna, Madaleno, Carolina Silva, Tenreiro, Sandra, Ventura, Salvador, Outeiro, Tiago F.
Publicado no Acta Neuropathol Commun (2016)

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

Por Moree, Ben, Yin, Guowei, Lázaro, Diana F., Munari, Francesca, Strohäker, Timo, Giller, Karin, Becker, Stefan, Outeiro, Tiago F., Zweckstetter, Markus, Salafsky, Joshua
Publicado no J Biol Chem (2015)

Glycation potentiates neurodegeneration in models of Huntington’s disease

Por Vicente Miranda, Hugo, Gomes, Marcos António, Branco-Santos, Joana, Breda, Carlo, Lázaro, Diana F., Lopes, Luísa Vaqueiro, Herrera, Federico, Giorgini, Flaviano, Outeiro, Tiago Fleming
Publicado no Sci Rep (2016)

Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death

Por Turriani, Elisa, Lázaro, Diana F., Ryazanov, Sergey, Leonov, Andrei, Giese, Armin, Schön, Margarete, Schön, Michael P., Griesinger, Christian, Outeiro, Tiago F., Arndt-Jovin, Donna J., Becker, Dorothea
Publicado no Proc Natl Acad Sci U S A (2017)

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells

Por Gustafsson, Gabriel, Lööv, Camilla, Persson, Emma, Lázaro, Diana F., Takeda, Shuko, Bergström, Joakim, Erlandsson, Anna, Sehlin, Dag, Balaj, Leonora, György, Bence, Hallbeck, Martin, Outeiro, Tiago F., Breakefield, Xandra O., Hyman, Bradley T., Ingelsson, Martin
Publicado no Cell Mol Neurobiol (2018)

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

Por Lázaro, Diana F., Rodrigues, Eva F., Langohr, Ramona, Shahpasandzadeh, Hedieh, Ribeiro, Thales, Guerreiro, Patrícia, Gerhardt, Ellen, Kröhnert, Katharina, Klucken, Jochen, Pereira, Marcos D., Popova, Blagovesta, Kruse, Niels, Mollenhauer, Brit, Rizzoli, Silvio O., Braus, Gerhard H., Danzer, Karin M., Outeiro, Tiago F.
Publicado no PLoS Genet (2014)

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Por Pujols, Jordi, Peña-Díaz, Samuel, Lázaro, Diana F., Peccati, Francesca, Pinheiro, Francisca, González, Danilo, Carija, Anita, Navarro, Susanna, Conde-Giménez, María, García, Jesús, Guardiola, Salvador, Giralt, Ernest, Salvatella, Xavier, Sancho, Javier, Sodupe, Mariona, Outeiro, Tiago Fleming, Dalfó, Esther, Ventura, Salvador
Publicado no Proc Natl Acad Sci U S A (2018)

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Por de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M., Martinho, Renato, Munari, Francesca, Lázaro, Diana F., Moniot, Sébastien, Guerreiro, Patrícia, Fonseca, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Publicado no PLoS Biol (2017)

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Por de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M., Martinho, Renato, Munari, Francesca, Lázaro, Diana F., Moniot, Sébastien, Guerreiro, Patrícia, Fonseca-Ornelas, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Publicado no PLoS Biol (2017)

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy

Por Richter, Katharina N, Revelo, Natalia H, Seitz, Katharina J, Helm, Martin S, Sarkar, Deblina, Saleeb, Rebecca S, D'Este, Elisa, Eberle, Jessica, Wagner, Eva, Vogl, Christian, Lazaro, Diana F, Richter, Frank, Coy‐Vergara, Javier, Coceano, Giovanna, Boyden, Edward S, Duncan, Rory R, Hell, Stefan W, Lauterbach, Marcel A, Lehnart, Stephan E, Moser, Tobias, Outeiro, Tiago F, Rehling, Peter, Schwappach, Blanche, Testa, Ilaria, Zapiec, Bolek, Rizzoli, Silvio O
Publicado no EMBO J (2017)