Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

Proteins are structurally dynamic molecules that perform specialized functions through unique conformational changes accessible in physiological environments. An ability to specifically and selectively control protein function via conformational modulation is an important goal for development of nov...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Moree, Ben, Yin, Guowei, Lázaro, Diana F., Munari, Francesca, Strohäker, Timo, Giller, Karin, Becker, Stefan, Outeiro, Tiago F., Zweckstetter, Markus, Salafsky, Joshua
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Molecular Biophysics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646010/
https://ncbi.nlm.nih.gov/pubmed/26396193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.636027
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