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Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. The di...
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| Publicado no: | Redox Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6375061/ https://ncbi.nlm.nih.gov/pubmed/30769283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101135 |
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