Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of intracellular protein inclusions, known as Lewy bodies and Lewy neurites, which are m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Pujols, Jordi, Peña-Díaz, Samuel, Lázaro, Diana F., Peccati, Francesca, Pinheiro, Francisca, González, Danilo, Carija, Anita, Navarro, Susanna, Conde-Giménez, María, García, Jesús, Guardiola, Salvador, Giralt, Ernest, Salvatella, Xavier, Sancho, Javier, Sodupe, Mariona, Outeiro, Tiago Fleming, Dalfó, Esther, Ventura, Salvador
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2018
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187188/
https://ncbi.nlm.nih.gov/pubmed/30249646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804198115
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