Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of intracellular protein inclusions, known as Lewy bodies and Lewy neurites, which are m...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pujols, Jordi, Peña-Díaz, Samuel, Lázaro, Diana F., Peccati, Francesca, Pinheiro, Francisca, González, Danilo, Carija, Anita, Navarro, Susanna, Conde-Giménez, María, García, Jesús, Guardiola, Salvador, Giralt, Ernest, Salvatella, Xavier, Sancho, Javier, Sodupe, Mariona, Outeiro, Tiago Fleming, Dalfó, Esther, Ventura, Salvador
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187188/
https://ncbi.nlm.nih.gov/pubmed/30249646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804198115
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