The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Lázaro, Diana F., Dias, Mariana Castro, Carija, Anita, Navarro, Susanna, Madaleno, Carolina Silva, Tenreiro, Sandra, Ventura, Salvador, Outeiro, Tiago F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148884/
https://ncbi.nlm.nih.gov/pubmed/27938414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0402-8
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