The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Lázaro, Diana F., Dias, Mariana Castro, Carija, Anita, Navarro, Susanna, Madaleno, Carolina Silva, Tenreiro, Sandra, Ventura, Salvador, Outeiro, Tiago F.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148884/
https://ncbi.nlm.nih.gov/pubmed/27938414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0402-8
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