Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

Proteins are structurally dynamic molecules that perform specialized functions through unique conformational changes accessible in physiological environments. An ability to specifically and selectively control protein function via conformational modulation is an important goal for development of nov...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Moree, Ben, Yin, Guowei, Lázaro, Diana F., Munari, Francesca, Strohäker, Timo, Giller, Karin, Becker, Stefan, Outeiro, Tiago F., Zweckstetter, Markus, Salafsky, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646010/
https://ncbi.nlm.nih.gov/pubmed/26396193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.636027
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