The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanis...

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Publicat a:PLoS Biol
Autors principals: de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M., Martinho, Renato, Munari, Francesca, Lázaro, Diana F., Moniot, Sébastien, Guerreiro, Patrícia, Fonseca, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336201/
https://ncbi.nlm.nih.gov/pubmed/28257421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000374
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