The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

Deleterious sustained inflammation mediated by activated microglia is common to most of neurologic disorders. Here, we identified sirtuin 2 (SIRT2), an abundant deacetylase in the brain, as a major inhibitor of microglia-mediated inflammation and neurotoxicity. SIRT2-deficient mice (SIRT2(−/−)) show...

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Hauptverfasser: Pais, Teresa Faria, Szegő, Éva M, Marques, Oldriska, Miller-Fleming, Leonor, Antas, Pedro, Guerreiro, Patrícia, de Oliveira, Rita Machado, Kasapoglu, Burcu, Outeiro, Tiago Fleming
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Molecular Biology Organization 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791374/
https://ncbi.nlm.nih.gov/pubmed/24013120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.200
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