Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

Por Mompeán, Miguel, Chakrabartty, Avijit, Buratti, Emanuele, Laurents, Douglas V.
Publicado no PLoS Biol (2016)

An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

Por Mompeán, Miguel, Baralle, Marco, Buratti, Emanuele, Laurents, Douglas V.
Publicado no Front Mol Neurosci (2016)

Folding pathway of the pyridoxal 5′-phosphate C-S lyase MalY from Escherichia coli

Por Bertoldi, Mariarita, Cellini, Barbara, Laurents, Douglas V., Borri Voltattorni, Carla
Publicado em 2005

Destabilizing Mutations Alter the Hydrogen Exchange Mechanism in Ribonuclease A

Por Bruix, Marta, Ribó, Marc, Benito, Antoni, Laurents, Douglas V., Rico, Manuel, Vilanova, Maria
Publicado em 2008

Interactions Crucial for Three-Dimensional Domain Swapping in the HP-RNase Variant PM8

Por Tubert, Pere, Laurents, Douglas V., Ribó, Marc, Bruix, Marta, Vilanova, Maria, Benito, Antoni
Publicado em 2011

Towards Tricking a Pathogen’s Protease into Fighting Infection: The 3D Structure of a Stable Circularly Permuted Onconase Variant Cleavedby HIV-1 Protease

Por Callís, Mariona, Serrano, Soraya, Benito, Antoni, Laurents, Douglas V., Vilanova, Maria, Bruix, Marta, Ribó, Marc
Publicado em 2013

Double Domain Swapping in Bovine Seminal RNase: Formation of Distinct N- and C-swapped Tetramers and Multimers with Increasing Biological Activities

Por Gotte, Giovanni, Mahmoud Helmy, Alexander, Ercole, Carmine, Spadaccini, Roberta, Laurents, Douglas V., Donadelli, Massimo, Picone, Delia
Publicado em 2012

Getting specificity from simplicity in putative proteins from the prebiotic Earth

Por López de la Osa, Jaime, Bateman, David A., Ho, Sylvia, González, Carlos, Chakrabartty, Avijit, Laurents, Douglas V.
Publicado em 2007

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

Por Mompeán, Miguel, Romano, Valentina, Pantoja-Uceda, David, Stuani, Cristiana, Baralle, Francisco E., Buratti, Emanuele, Laurents, Douglas V.
Publicado no J Biol Chem (2017)

Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei

Por Ibrahim, B. Syed, Kanneganti, Nalini, Rieckhof, Gabrielle E., Das, Anish, Laurents, Douglas V., Palenchar, Jennifer B., Bellofatto, Vivian, Wah, David A.
Publicado em 2009

NMR Structural Determinants of Eosinophil Cationic Protein Binding to Membrane and Heparin Mimetics

Por García-Mayoral, María Flor, Moussaoui, Mohammed, de la Torre, Beatriz G., Andreu, David, Boix, Ester, Nogués, M. Victòria, Rico, Manuel, Laurents, Douglas V., Bruix, Marta
Publicado em 2010

Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43

Por Mompeán, Miguel, Hervás, Rubén, Xu, Yunyao, Tran, Timothy H., Guarnaccia, Corrado, Buratti, Emanuele, Baralle, Francisco, Tong, Liang, Carrión-Vázquez, Mariano, McDermott, Ann E., Laurents, Douglas V.
Publicado no J Phys Chem Lett (2015)

Common Features at the Start of the Neurodegeneration Cascade

Por Hervás, Rubén, Oroz, Javier, Galera-Prat, Albert, Goñi, Oscar, Valbuena, Alejandro, Vera, Andrés M., Gómez-Sicilia, Àngel, Losada-Urzáiz, Fernando, Uversky, Vladimir N., Menéndez, Margarita, Laurents, Douglas V., Bruix, Marta, Carrión-Vázquez, Mariano
Publicado em 2012

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation

Por Hervás, Rubén, Li, Liying, Majumdar, Amitabha, Fernández-Ramírez, María del Carmen, Unruh, Jay R., Slaughter, Brian D., Galera-Prat, Albert, Santana, Elena, Suzuki, Mari, Nagai, Yoshitaka, Bruix, Marta, Casas-Tintó, Sergio, Menéndez, Margarita, Laurents, Douglas V., Si, Kausik, Carrión-Vázquez, Mariano
Publicado no PLoS Biol (2016)