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Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
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| Publicado no: | PLoS Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838238/ https://ncbi.nlm.nih.gov/pubmed/27096426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002447 |
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