Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

Transactive response DNA-binding protein 43 (TDP-43) performs multiple tasks in mRNA processing, transport, and translational regulation, but it also forms aggregates implicated in amyotrophic lateral sclerosis. TDP-43's N-terminal domain (NTD) is important for these activities and dysfunctions...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mompeán, Miguel, Romano, Valentina, Pantoja-Uceda, David, Stuani, Cristiana, Baralle, Francisco E., Buratti, Emanuele, Laurents, Douglas V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512090/
https://ncbi.nlm.nih.gov/pubmed/28566288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775965
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