Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43

TDP-43 can form pathological proteinaceous aggregates linked to ALS and FTLD. Within the putative aggregation domain, engineered repeats of residues 341–366 can recruit endogenous TDP-43 into aggregates inside cells; however, the nature of these aggregates is a debatable issue. Recently, we showed t...

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Detalhes bibliográficos
Publicado no:J Phys Chem Lett
Main Authors: Mompeán, Miguel, Hervás, Rubén, Xu, Yunyao, Tran, Timothy H., Guarnaccia, Corrado, Buratti, Emanuele, Baralle, Francisco, Tong, Liang, Carrión-Vázquez, Mariano, McDermott, Ann E., Laurents, Douglas V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568655/
https://ncbi.nlm.nih.gov/pubmed/26266742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.5b00918
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