Towards Tricking a Pathogen’s Protease into Fighting Infection: The 3D Structure of a Stable Circularly Permuted Onconase Variant Cleavedby HIV-1 Protease

Onconase® is a highly cytotoxic amphibian homolog of Ribonuclease A. Here, we describe the construction of circularly permuted Onconase® variants by connecting the N- and C-termini of this enzyme with amino acid residues that are recognized and cleaved by the human immunodeficiency virus protease. U...

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Bibliographic Details
Main Authors: Callís, Mariona, Serrano, Soraya, Benito, Antoni, Laurents, Douglas V., Vilanova, Maria, Bruix, Marta, Ribó, Marc
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548804/
https://ncbi.nlm.nih.gov/pubmed/23349931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054568
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