A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis

by Knudson, Susan E., Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélèn, Ojima, Iwao, Slayden, Richard A.
Published 2014

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model

by Knudson, Susan E., Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélène, Ojima, Iwao, Slayden, Richard A.
Published in J Antimicrob Chemother (2015)

Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence

by Bade, Pauline, Simonetti, Fabrizio, Sans, Stephanie, Laboudie, Patricia, Kissane, Khadija, Chappat, Nicolas, Lagrange, Sophie, Apparailly, Florence, Roubert, Christine, Duroux-Richard, Isabelle
Published in Front Immunol (2021)

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

by Huszár, Stanislav, Singh, Vinayak, Polčicová, Alica, Baráth, Peter, Barrio, María Belén, Lagrange, Sophie, Leblanc, Véronique, Nacy, Carol A., Mizrahi, Valerie, Mikušová, Katarína
Published in Antimicrob Agents Chemother (2017)

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

by Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Published in ACS Infect Dis (2016)

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

by Lopez Quezada, Landys, Silve, Sandra, Kelinske, Mark, Liba, Amir, Diaz Gonzalez, Constantino, Kotev, Martin, Goullieux, Laurent, Sans, Stephanie, Roubert, Christine, Lagrange, Sophie, Bacqué, Eric, Couturier, Cedric, Pellet, Alain, Blanc, Isabelle, Ferron, Marlène, Debu, Fabrice, Li, Kelin, Aubé, Jeffrey, Roberts, Julia, Little, David, Ling, Yan, Zhang, Jun, Gold, Ben, Nathan, Carl
Published in mBio (2019)

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

by Ballinger, Elaine, Mosior, John, Hartman, Travis, Burns-Huang, Kristin, Gold, Ben, Morris, Roxanne, Goullieux, Laurent, Blanc, Isabelle, Vaubourgeix, Julien, Lagrange, Sophie, Fraisse, Laurent, Sans, Stéphanie, Couturier, Cedric, Bacqué, Eric, Rhee, Kyu, Scarry, Sarah M., Aubé, Jeffrey, Yang, Guangbin, Ouerfelli, Ouathek, Schnappinger, Dirk, Ioerger, Thomas R., Engelhart, Curtis A., McConnell, Jennifer A., McAulay, Kathrine, Fay, Allison, Roubert, Christine, Sacchettini, James, Nathan, Carl
Published in Science (2019)

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis

by Qpezada, Landys Lopez, Li, Kelin, McDonald, Stacey L., Nguyen, Quyen, Perkowski, Andrew J., Pharr, Cameron W., Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Karakaya, Selin Somersan, Javidnia, Prisca Elis, de Francisco, Esther Porras, Amieva, Manuel Marin, Díaz, Sara Palomo, Losana, Alfonso Mendoza, Zimmerman, Matthew, Ho Liang, Hsin-Pin, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey
Published in ACS Infect Dis (2019)