Linking uric acid metabolism to diabetic complications

Por Kushiyama, Akifumi, Tanaka, Kentaro, Hara, Shigeko, Kawazu, Shoji
Publicado no World J Diabetes (2014)

Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS

Por Matsuzaki, Gen, Kushiyama, Akifumi, Uto, Kenta, Shoda, Morio, Seko, Yoshinori
Publicado em 2011

Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes

Por Tanaka, Kentaro, Hara, Shigeko, Hattori, Masakazu, Sakai, Ken, Onishi, Yukiko, Yoshida, Yoko, Kawazu, Shoji, Kushiyama, Akifumi
Publicado no J Diabetes Investig (2015)

Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1

Por Kushiyama, Akifumi, Kikuchi, Takako, Tanaka, Kentaro, Tahara, Tazu, Takao, Toshiko, Onishi, Yukiko, Yoshida, Yoko, Kawazu, Shoji, Iwamoto, Yasuhiko
Publicado no World J Diabetes (2016)

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice

Por Shinjo, Takanori, Nakatsu, Yusuke, Iwashita, Misaki, Sano, Tomomi, Sakoda, Hideyuki, Ishihara, Hisamitsu, Kushiyama, Akifumi, Fujishiro, Midori, Nishimura, Fusanori, Asano, Tomoichiro
Publicado no Diabetol Metab Syndr (2015)

Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus

Por Fujishiro, Midori, Kushiyama, Akifumi, Yamazaki, Hiroki, Kaneko, Sunao, Koketsu, Yuko, Yamamotoya, Takeshi, Kikuchi, Takako, Sakoda, Hideyuki, Suzuki, Ryo, Kadowaki, Takashi
Publicado no World J Gastroenterol (2017)

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoe...

Por Horike, Nanao, Sakoda, Hideyuki, Kushiyama, Akifumi, Ono, Hiraku, Fujishiro, Midori, Kamata, Hideaki, Nishiyama, Koichi, Uchijima, Yasunobu, Kurihara, Yukiko, Kurihara, Hiroki, Asano, Tomoichiro
Publicado em 2008

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice

Por Iwashita, Misaki, Nakatsu, Yusuke, Sakoda, Hideyuki, Fujishiro, Midori, Kushiyama, Akifumi, Fukushima, Toshiaki, Kumamoto, Sonoko, Shinjo, Takanori, Kamata, Hideaki, Nishimura, Fusanori, Asano, Tomoichiro
Publicado em 2013

Twenty‐year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan

Por Kushiyama, Akifumi, Yoshida, Yoko, Kikuchi, Takako, Suzawa, Naoki, Yamamoto, Mayumi, Tanaka, Kentaro, Okayasu, Mineko, Tahara, Tazu, Takao, Toshiko, Onishi, Yukiko, Kawazu, Shoji
Publicado em 2013

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus

Por Qiang, Shirong, Nakatsu, Yusuke, Seno, Yasuyuki, Fujishiro, Midori, Sakoda, Hideyuki, Kushiyama, Akifumi, Mori, Keiichi, Matsunaga, Yasuka, Yamamotoya, Takeshi, Kamata, Hideaki, Asano, Tomoichiro
Publicado no Diabetol Metab Syndr (2015)

C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus

Por Sonoda, Remi, Tanaka, Kentaro, Kikuchi, Takako, Onishi, Yukiko, Takao, Toshiko, Tahara, Tazu, Yoshida, Yoko, Suzawa, Naoki, Kawazu, Shoji, Iwamoto, Yasuhiko, Kushiyama, Akifumi
Publicado no PLoS One (2016)

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations

Por Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Yuki, Mori, Keiichi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro
Publicado no Int J Mol Sci (2016)

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis

Por Kushiyama, Akifumi, Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Mori, Keiichi, Ueda, Koji, Inoue, Yuki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Asano, Tomoichiro
Publicado no Mediators Inflamm (2016)

Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice

Por Yamamotoya, Takeshi, Nakatsu, Yusuke, Matsunaga, Yasuka, Fukushima, Toshiaki, Yamazaki, Hiroki, Kaneko, Sunao, Fujishiro, Midori, Kikuchi, Takako, Kushiyama, Akifumi, Tokunaga, Fuminori, Asano, Tomoichiro, Sakoda, Hideyuki
Publicado no Int J Mol Sci (2017)

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines

Por Kanaoka, Ryuhei, Kushiyama, Akifumi, Seno, Yasuyuki, Nakatsu, Yusuke, Matsunaga, Yasuka, Fukushima, Toshiaki, Tsuchiya, Yoshihiro, Sakoda, Hideyuki, Fujishiro, Midori, Yamamotoya, Takeshi, Kamata, Hideaki, Matsubara, Akio, Asano, Tomoichiro
Publicado no PLoS One (2015)

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity

Por Yamamotoya, Takeshi, Nakatsu, Yusuke, Kushiyama, Akifumi, Matsunaga, Yasuka, Ueda, Koji, Inoue, Yuki, Inoue, Masa-Ki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kiyonari, Hiroshi, Ishihara, Hisamitsu, Asano, Tomoichiro
Publicado no Sci Rep (2017)

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion

Por Nakatsu, Yusuke, Mori, Keiichi, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Yuki, Mitsuzaki-Miyoshi, Keiko, Sakoda, Hideyuki, Fujishiro, Midori, Yamaguchi, Suguru, Kushiyama, Akifumi, Ono, Hiraku, Ishihara, Hisamitsu, Asano, Tomoichiro
Publicado no J Biol Chem (2017)

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic A...

Por Nakatsu, Yusuke, Kokubo, Hiroki, Bumdelger, Batmunkh, Yoshizumi, Masao, Yamamotoya, Takeshi, Matsunaga, Yasuka, Ueda, Koji, Inoue, Yuki, Inoue, Masa-Ki, Fujishiro, Midori, Kushiyama, Akifumi, Ono, Hiraku, Sakoda, Hideyuki, Asano, Tomoichiro
Publicado no Int J Mol Sci (2017)

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

Por Matsunaga, Yasuka, Nakatsu, Yusuke, Fukushima, Toshiaki, Okubo, Hirofumi, Iwashita, Misaki, Sakoda, Hideyuki, Fujishiro, Midori, Yamamotoya, Takeshi, Kushiyama, Akifumi, Takahashi, Shin-ichiro, Tsuchiya, Yoshihiro, Kamata, Hideaki, Tokunaga, Fuminori, Iwai, Kazuhiro, Asano, Tomoichiro
Publicado no Mediators Inflamm (2015)

Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit

Por Nakatsu, Yusuke, Iwashita, Misaki, Sakoda, Hideyuki, Ono, Hiraku, Nagata, Kengo, Matsunaga, Yasuka, Fukushima, Toshiaki, Fujishiro, Midori, Kushiyama, Akifumi, Kamata, Hideaki, Takahashi, Shin-Ichiro, Katagiri, Hideki, Honda, Hiroaki, Kiyonari, Hiroshi, Uchida, Takafumi, Asano, Tomoichiro
Publicado no J Biol Chem (2015)