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The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion
The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to show that Pin1 expression in pancreatic β cells is markedly elevated by high-fat diet feeding and in ob/ob mice. To elucidate the role of Pi...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512081/ https://ncbi.nlm.nih.gov/pubmed/28566287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780726 |
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