Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit

AMP-activated protein kinase (AMPK) plays a critical role in metabolic regulation. In this study, first, it was revealed that Pin1 associates with any isoform of γ, but not with either the α or the β subunit, of AMPK. The association between Pin1 and the AMPK γ1 subunit is mediated by the WW domain...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nakatsu, Yusuke, Iwashita, Misaki, Sakoda, Hideyuki, Ono, Hiraku, Nagata, Kengo, Matsunaga, Yasuka, Fukushima, Toshiaki, Fujishiro, Midori, Kushiyama, Akifumi, Kamata, Hideaki, Takahashi, Shin-Ichiro, Katagiri, Hideki, Honda, Hiroaki, Kiyonari, Hiroshi, Uchida, Takafumi, Asano, Tomoichiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591812/
https://ncbi.nlm.nih.gov/pubmed/26276391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658559
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