Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation

The prolyl isomerase Pin1 expression level is reportedly increased in most malignant tissues and correlates with poor outcomes. On the other hand, acetyl CoA carboxylase 1 (ACC1), the rate limiting enzyme of lipogenesis is also abundantly expressed in cancer cells, to satisfy the demand for the fatt...

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Pubblicato in:Oncotarget
Autori principali: Ueda, Koji, Nakatsu, Yusuke, Yamamotoya, Takeshi, Ono, Hiraku, Inoue, Yuki, Inoue, Masa-Ki, Mizuno, Yu, Matsunaga, Yasuka, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Takahashi, Shin-Ichiro, Matsubara, Akio, Asano, Tomoichiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422191/
https://ncbi.nlm.nih.gov/pubmed/30899433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26691
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