Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompanying inflammation. Indeed, Pin1-deficient mice are highly resi...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Inoue, Masa-Ki, Nakatsu, Yusuke, Yamamotoya, Takeshi, Hasei, Shun, Kanamoto, Mayu, Naitou, Miki, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952946/
https://ncbi.nlm.nih.gov/pubmed/31795496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121545
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