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Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins
Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompanying inflammation. Indeed, Pin1-deficient mice are highly resi...
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| Publié dans: | Cells |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952946/ https://ncbi.nlm.nih.gov/pubmed/31795496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121545 |
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